Something’s gotta give at the centromeric chromatin foundation of the kinetochore
Kixmoeller K, Allu PK, Black BE. Something’s gotta give at the centromeric chromatin foundation of the kinetochore. Mol Cell. 2022 Jun 2;82(11):1976-1978. doi: 10.1016/j.molcel.2022.05.011. PMID: 35659323.
Abstract
Structures of the reconstituted human inner kinetochore complex by Pesenti et al. (2022) and Yatskevich et al. (2022) raise the question of whether it is the CENP-A nucleosome or the CCAN complex itself that provides the foundation for kinetochore assembly.