Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2
Fehrentz T, Amin E, Görldt N, Strasdeit T, Moussavi-Torshizi SE, Leippe P, Trauner D, Meyer C, Frey N, Sasse P, Klöcker N. Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. Br J Pharmacol. 2024 Nov 14. doi: 10.1111/bph.17394. Epub ahead of print. PMID: 39543799.
Abstract
Background and purpose: Patients suffering from ischaemic heart disease and heart failure are at high risk of recurrent ventricular arrhythmias (VAs), eventually leading to sudden cardiac death. While high-voltage shocks delivered by an implantable defibrillator may prevent sudden cardiac death, these interventions themselves impair quality of life and raise both morbidity and mortality, which accentuates the need for developing novel defibrillation techniques.